Cerebral Blood Flow Velocity Parameters Among Chronic Alcohol Dependent Patients Following Detoxification: A Cross-Sectional Study.

Sanjaya Kumar Pany; Rati Ranjan Sethy; Aniket Dash; S. A. Idrees

doi:10.51168/62y9f469

Autori

Sanjaya Kumar Pany Associate Professor, Department of Psychiatry, Hi Tech Medical College, Bhubaneswar, Odisha, India
Rati Ranjan Sethy Associate Professor, Department of Psychiatry, Government Medical College & Hospital, Phulbani, Odisha, India
Aniket Dash Assistant Professor, Department of Psychiatry, Pabitra Mohan Pradhan Medical College & Hospital, Talcher, Odisha , India
S. A. Idrees Associate Professor, Department of Psychiatry, Hi Tech Medical College and Hospital, Bhubaneswar, Odisha, India

DOI:

https://doi.org/10.51168/62y9f469

Cuvinte cheie:

Alcohol dependence syndrome, Cerebral blood flow velocity, Transcranial Doppler ultrasonography, Detoxification, Cerebral hemodynamics

Rezumat

Background:

Chronic alcohol dependence is associated with neurovascular alterations that may impair cerebral blood flow and autoregulation. Although detoxification is a key component of treatment, cerebral hemodynamic abnormalities may persist after withdrawal. Evidence regarding cerebral blood flow velocity following detoxification remains limited, particularly in the Indian population.

Objectives:

To evaluate cerebral blood flow velocity parameters among chronic alcohol-dependent patients following detoxification using Transcranial Doppler ultrasonography and determine their association with clinical and demographic variables.

Methods:

A hospital-based cross-sectional analytical study was conducted among 60 male patients with alcohol dependence syndrome who had completed detoxification at the Central Institute of Psychiatry, Kanke, Ranchi. Participants were recruited using consecutive sampling. Clinical assessment included sociodemographic characteristics, alcohol use profile, and Severity of Alcohol Dependence Questionnaire (SADQ) scores. Cerebral hemodynamic parameters were measured using Transcranial Doppler ultrasonography. Data were analyzed using descriptive statistics, independent t-test, one-way ANOVA, Pearson correlation, and multiple linear regression.

Results:

The mean age of participants was 36.8 ± 7.4 years, and the mean duration of alcohol use was 14.2 ± 6.1 years. Severe alcohol dependence was associated with significantly lower middle cerebral artery mean velocities and higher pulsatility indices (p < 0.05). Duration of alcohol use showed a significant negative correlation with right middle cerebral artery mean velocity (r = −0.42, p = 0.010) and independently predicted reduced cerebral blood flow velocity.

Conclusion:

Chronic alcohol dependence is associated with persistent cerebral hemodynamic alterations despite detoxification. Longer duration and greater severity of alcohol exposure are associated with impaired cerebral circulation.

Recommendation:

Longitudinal multicenter studies with larger sample sizes are recommended to evaluate long-term neurovascular recovery following sustained abstinence.

Biografii autori

Sanjaya Kumar Pany, Associate Professor, Department of Psychiatry, Hi Tech Medical College, Bhubaneswar, Odisha, India

is an Associate Professor in the Department of Psychiatry, Hi-Tech Medical College, Bhubaneswar, Odisha, India. His research interests include addiction psychiatry, neuropsychiatry, and psychiatric epidemiology.
Rati Ranjan Sethy, Associate Professor, Department of Psychiatry, Government Medical College & Hospital, Phulbani, Odisha, India

is an Associate Professor in the Department of Psychiatry, Government Medical College and Hospital, Phulbani, Odisha, India. His areas of interest include substance use disorders, community psychiatry, and mental health services research.
Aniket Dash, Assistant Professor, Department of Psychiatry, Pabitra Mohan Pradhan Medical College & Hospital, Talcher, Odisha , India

is an Assistant Professor in the Department of Psychiatry, Pabitra Mohan Pradhan Medical College and Hospital, Talcher, Odisha, India. His research focuses on addiction medicine, clinical psychiatry, and neuropsychiatric disorders.
S. A. Idrees, Associate Professor, Department of Psychiatry, Hi Tech Medical College and Hospital, Bhubaneswar, Odisha, India

is an Associate Professor in the Department of Psychiatry, Hi-Tech Medical College and Hospital, Bhubaneswar, Odisha, India. His research interests include addiction psychiatry, neuroimaging, and clinical neuroscience.

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