Clinical Efficacy of Platelet-Rich Fibrin (PRF) in regenerative management of Endo-Perio defects: A prospective comparative clinical study.

Anamika; Kamil  Shahnawaz; Swati  Sagar

doi:10.51168/sjhrafrica.v7i3.2605

Autori

Anamika Senior Resident, Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.
Kamil Shahnawaz Senior Resident & H.O.D., Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.
Swati Sagar Senior Resident, Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.

DOI:

https://doi.org/10.51168/sjhrafrica.v7i3.2605

Cuvinte cheie:

Platelet-Rich Fibrin, Endo-Perio Lesions, Periodontal Regeneration, Growth Factors, Dental Research

Rezumat

Background

Endodontic–periodontal (endo-perio) lesions are challenging conditions requiring coordinated management of pulpal and periodontal tissues. Platelet-Rich Fibrin (PRF), an autologous platelet concentrate rich in growth factors, has emerged as a promising regenerative adjunct.

Aim: To evaluate the clinical efficacy of PRF in the regenerative management of endo-perio defects.

Materials and methods

This prospective comparative clinical study included 100 patients with endo-perio defects treated at the Department of Dentistry, Darbhanga Medical College and Hospital, Bihar, India. Participants were consecutively recruited and allocated into two groups: Group A (conventional endodontic-periodontal therapy; n=50) and Group B (conventional therapy plus PRF application; n=50). Clinical parameters, including probing pocket depth (PPD), clinical attachment level (CAL), and radiographic bone defect depth, were assessed at baseline and after six months.

Results

Of the 100 participants, 58% were males and 42% were females, with the majority (64%) aged 31–50 years. Baseline characteristics were comparable between groups. At six months, the PRF group demonstrated significantly greater PPD reduction (3.82±0.84 mm vs. 2.11±0.73 mm), CAL gain (4.03±0.86 mm vs. 2.08±0.72 mm), and radiographic bone fill (3.11±0.73 mm vs. 1.61±0.62 mm) than the control group (all p<0.001).

Conclusion

PRF significantly enhances periodontal regeneration when used as an adjunct to conventional therapy for endo-perio defects.

Recommendation

PRF may be considered a useful adjunct in the routine regenerative management of suitable endo-perio lesions. Larger multicenter randomized controlled studies with longer follow-up are recommended to confirm these findings.

Biografii autori

Anamika, Senior Resident, Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.

is a Senior Resident in the Department of Dentistry, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India. Her clinical and research interests include endodontics, periodontology, regenerative dentistry, and evidence-based dental practice.
Kamil Shahnawaz, Senior Resident & H.O.D., Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.

is Senior Resident and Head of the Department of Dentistry at Darbhanga Medical College and Hospital, Darbhanga, Bihar, India. His areas of expertise include periodontology, oral implantology, regenerative dental procedures, and clinical research.
Swati Sagar, Senior Resident, Department of Dentistry, Darbhanga Medical College & Hospital, Darbhanga, Bihar, India.

is a Senior Resident in the Department of Dentistry, Darbhanga Medical College and Hospital, Darbhanga, Bihar, India. Her research interests include periodontal therapy, restorative dentistry, preventive oral healthcare, and clinical outcome research.

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