The effect of topical 2% hydrogen peroxide versus normal saline dressing on split-thickness skin grafts in diabetic foot patients – a randomized controlled trial

Baitha Kanchan Lal Baitha; Kumar Anunay; Ranjan Rajeev; Nadeem Ahmed; Prakash Prem; Kumari

doi:10.51168/pfsyra33

Autori

Baitha Kanchan Lal Baitha Additional Professor, Department of General Surgery, IGIMS, Patna, Bihar, India
Kumar Anunay Senior Resident, Department of General Surgery, IGIMS, Patna, Bihar, India
Ranjan Rajeev Senior Resident, Department of General Surgery, IGIMS, Patna, Bihar, India
Nadeem Ahmed Additional Professor, Department of General Surgery, IGIMS, Patna, Bihar, India
Prakash Prem Professor, Department of General Surgery, IGIMS, Patna, Bihar, India
Kumari Additional Professor, Department of General Surgery, IGIMS, Patna, India

DOI:

https://doi.org/10.51168/pfsyra33

Cuvinte cheie:

Diabetic foot ulcer, split-thickness skin graft, hydrogen peroxide, wound dressing, graft uptake, angiogenesis, randomized controlled trial

Rezumat

Background:

Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus and are associated with impaired wound healing and an increased risk of lower-extremity amputation. Split-thickness skin grafting (STSG) provides effective wound coverage, but graft failure remains a concern in diabetic patients. Hydrogen peroxide (H₂O₂) has antimicrobial and potentially pro-healing properties that may improve graft outcomes.

Methods:

This prospective, open-label, parallel-group randomized controlled trial is being conducted in the Department of General Surgery, Indira Gandhi Institute of Medical Sciences (IGIMS), Patna. Thirty diabetic foot patients aged 18–75 years undergoing STSG will be randomized equally to receive either 2% H₂O₂ dressing (group a) or normal saline dressing (group b). The primary outcomes are percentage graft take, graft viability, and time to complete wound closure. Graft adherence, pain, bleeding, infection, and other postoperative complications will also be assessed.

Results:

The trial is ongoing, and final quantitative outcome data are not yet available. Participants are being followed prospectively according to the predefined postoperative dressing protocol. Comparative assessment of percentage graft take, graft viability, wound closure, and postoperative complications between the two groups will be performed after completion of the study.

Conclusion:

The study will provide comparative evidence on the effectiveness and safety of 2% H₂O₂versus normal saline dressing following STSG in diabetic foot patients.

Recommendation:

The routine use of 2% H₂O₂ should be considered only after confirmation of its efficacy and safety through the completed trial.

Biografii autori

Baitha Kanchan Lal Baitha, Additional Professor, Department of General Surgery, IGIMS, Patna, Bihar, India

is an additional professor in the Department of General Surgery at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India. Her professional interests include general surgery, surgical wound management, and clinical research.
Kumar Anunay, Senior Resident, Department of General Surgery, IGIMS, Patna, Bihar, India

is a senior resident in the Department of General Surgery at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India. His clinical and academic interests include general surgery and surgical management of complex wounds
Ranjan Rajeev, Senior Resident, Department of General Surgery, IGIMS, Patna, Bihar, India

is a senior resident in the Department of General Surgery at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India. His professional interests include general surgery and clinical research.
Nadeem Ahmed, Additional Professor, Department of General Surgery, IGIMS, Patna, Bihar, India

is an additional professor in the Department of General Surgery at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India. His areas of professional interest include general surgery, surgical wound management, and clinical research.
Prakash Prem, Professor, Department of General Surgery, IGIMS, Patna, Bihar, India

is a professor in the Department of General Surgery at Indira Gandhi Institute of Medical Sciences (IGIMS), Patna, Bihar, India. He is involved in clinical practice, surgical education, and research in general surgery.

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